In hyperglycemia, the elevated glucose concentration competitively binds with GLUT to release Glu-INS for regulating BGLs.In diabetic rats, normoglycemia was achieved within 1 h and maintained at 200 mg/dL for over 5 h which was higher than injections.Sustained release and glucose-responsive release achieved. This evidence concerns the gene SLC2A1 and Hyperglycemia.