PROP1 and pituitary tumor: The involvement of PROP1 in the abnormal development of the anterior pituitary gland is indirectly supported by the presence of pituitary tumors characterized by an abnormal hypointense signal in T2-dependent MRI scans, which may increase or decrease, leading to hypoplasia of the pituitary gland over time in patients with CPHD-PROP1 [6, 46, 47].