Combined pituitary hormone deficiency (CPHD) is characterized by a deficiency of at least two of six anterior pituitary hormones, namely, growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), adrenocorticotropic hormone (ACTH), and at least one gonadotropin (LH, FSH). Here, POMC is linked to hypopituitarism.