CD38 and AL amyloidosis: CD38 is a commonly found ectoenzyme on plasma cells and multiple myeloma cells.9 Alloantibody-producing plasma cells express CD38 at a higher level than other CD38+ hematopoietic cells.9 There is thus a rationale for depleting plasma cells producing alloantibodies or donor-specific antibodies (DSAs) for desensitization in kidney transplant patients with CD38-targeting antibodies.