An example of reconstructing long-range haplotypes in the cluster of the SPANX-A/D gene sub-family, located within a 750 kb region at Xq27-q28 that is presumable involved in the hereditary prostate cancer locus HPCX1 [65, 66], is TAR isolation of individual SPANX genes. The gene discussed is SPANXA2; the disease is Familial prostate cancer.