The Norrie disease protein (NDP) gene (OMIM 300658) often result in a severe phenotype is located on chromosome Xp11.3 (ChrX: 4,36,92,969–4,37,17,694) (GRCh37) and is considered the pathogenic basis of ND (Berger et al., 1992; Chen et al., 1992). This evidence concerns the gene NDP and Norrie disease.