Interestingly, contradictory findings regarding SCD1 implication in metabolic syndrome development have demonstrated that while overactivation of SCD1 enzyme triggers insulin resistance and increased fat depots in rodents, SCD1 expression is inversely correlated with inflammation and insulin resistance in human patients (Peter et al., 2009; Gong et al., 2011), which strongly suggest that in horses, SCD1 loss is a hallmark of EMS and SAT metabolic instability. This evidence concerns the gene SCD and Insulin resistance.