Likewise, Kim and collaborators (Kim et al., 2017), found that changes in both VAT and SAT were inversely related to changes in SHBG, and that reduction in both VAT and SAT results in higher levels of SHBG in both men and women with diabetes, suggesting SHBG as a valuable candidate for obesity-associates complications intervention. This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.