Further to this, given that the homozygous FA-S patients seem to present with a more severe phenotype and ‘FA-like’ cancers, it would be of interest to follow-up with P5 and P7 to investigate whether they are later predisposed to breast/ovarian cancers [as in HBOC (BRCA1)] or not (as in other FA types). The gene discussed is BRCA1; the disease is ovarian carcinoma.