Remarkably mirroring the in vitro results, Fan treatment was found to facilitate autophagy in Aβ1-42-induced mouse model of AD, as shown by the restoration of P62 (n = 4, 99.40% ± 13.12%, p < 0.001 vs. WT + Aβ, p = 1.000 vs. WT; Figure 4B), Beclin-1 (n = 4, 98.08% ± 4.54%, p = 0.004 vs. WT + Aβ, p = 0.922 vs. WT; Figure 4C) and LC3-II (n = 3, 106.14% ± 18.81%, p = 0.009 vs. WT + Aβ, p = 0.925 vs. WT; Figure 4D). Here, BECN1 is linked to Alzheimer disease.