IL17A and rheumatoid arthritis: Human PBMCs were cultured for 48 h with stimuli to induce Th17 differentiation. Tocotrienol was cultured with PBMCs for 3 h before subjecting them to the same Th17 differentiation method. RA FLS were stimulated with IL-17. The FLS were cultured with or without tocotrienol for 3 h before the addition of IL-17. After stimulation for 72 h, mRNA was extracted.