ACTH leads to the secretion of cortisol and catecholamines21 resulting in a decrease in adiponectin and an increase in leptin, IL-6, TN-alpha, lipolysis, and insulin resistance.8 In short, short sleep duration has been reported to cause diabetes through insulin resistance, a sequela which contributes to the development of metabolic syndrome.24 The gene discussed is LEP; the disease is diabetes mellitus.