For example, we find that CYP3A4, ABCB1, ABCC2, SLCO1A2, proteins associated with the drug metabolism and transportation,28 are involved in 72,884 (66% of all) trials, while EGFR, TNF, TP53, proteins associated to auto-immune diseases and several neoplasms, are involved in 8,396 (8% of all) trials (Figure 2D). This evidence concerns the gene CYP3A4 and immune system disorder.