SERPINB10 and chronic obstructive pulmonary disease: Besides, note that restrictive and obstructive pulmonary diseases can have opposite effects on lung volume, which makes individual spirometry less sensitive in detecting clinically relevant changes, highlighting the role of CT in assessing this disease (5, 9), also Kahnert et al. (34) suggested Pi10 can be seen as an imaging biomarker for the course of COPD and response to treatment.