Positive anti-b2-GP I IgG (OR=6.649, 95%CI OR=1.21-36.40, p=0.029) and higher titer of anti-dsDNA (OR=1.004, 95%CI OR=1.00-1.01, p=0.001) were independent factors associated with lupus nephritis (Table 3). The gene discussed is GPI; the disease is lupus nephritis.