Guided by the knowledge gaps and numerous unsolved hypotheses about SLE evolution, the goals of this research were set: a) to investigate the association between the respondents’ characteristics, including the parameters of EBV infection and SLE; b) to explore whether pooled markers achieve a more significant effect on SLE development than each of them individually, c) to evaluate EBV EBNA1 and LMP1 gene polymorphisms in isolates from SLE patients. Here, PDLIM7 is linked to systemic lupus erythematosus.