Guided by the knowledge gaps and numerous unsolved hypotheses about SLE evolution, the goals of this research were set: a) to investigate the association between the respondents’ characteristics, including the parameters of EBV infection and SLE; b) to explore whether pooled markers achieve a more significant effect on SLE development than each of them individually, c) to evaluate EBV EBNA1 and LMP1 gene polymorphisms in isolates from SLE patients. The gene discussed is PDLIM7; the disease is Epstein-Barr virus infection.