GRM5 and nervous system disorder: We show that, in the presence of rTNF-α, mGluR5 inhibition decreases the secreted levels of IL-6 and IL-8 and increases the expression of the reactive astrocyte marker SERPINA3. Since reactive astrogliosis can display different functional profiles (44) and given its role in synaptic turnover, a process altered in many neurological diseases (45), we also assessed the rate of phagocytosis of synaptoneurosomes by astrocytes and the expression of synaptogenic proteins.