reported that their LGR5-redirected CAR-Ts mediated tumoricidal effects in an antigen density-dependent fashion, as they remarkably suppressed the outgrowth of the ovarian cancer cell lines COV318 and COV362 (which overexpress LGR5), while not enforcing the same reactions against SKOV3 and OV90 cell lines that display LGR5 on their surface at lower levels (61). Here, LGR5 is linked to ovarian carcinoma.