CD4 and neoplasm: Briefly, upon the administration of NKG2DL-redirected CAR-Ts into ID8-based preclinical mouse models, the researchers reported a CAR-T-induced increase in the population of tumor-resident endogenous CD4-positive T cells and CD8-positive T cells in a fashion dependent on CXCR3, as well as expansion in the population of tumor- and lymph-resident tumor-reactive endogenous CD4-positive T cells (127).