MSLN and neoplasm: Moreover, the investigators established human mesothelin-positive ovarian tumor mouse models (using 3 × 105 human mesothelin-positive Defb29 cells), and reported that a single round intraperitoneal administration of mesothelin-redirected CAR-Ts resulted in tumor outgrowth suppression and prolonged survival of the animal models in a CAR-T dose-dependent fashion (141).