Upon co-cultivation of the FRβ-redirected CAR-Ts (equipped with an scFv called m909 as the targeting domain) with the engineered C3023 cell line alongside other FRβ-positive AML cell lines, it was demonstrated that the CAR-Ts were capable of mediating antigen-dependent tumoricidal effects against the target cells (90). This evidence concerns the gene FOLR2 and acute myeloid leukemia.