CD47 and neoplasm: Despite the constitutive expression of CD47 (which acts as a “don’t eat me” signal to macrophages) on the surface of a vast variety of tumor cells, it is also displayed on the surface of healthy cells; therefore, to prevent dual CAR-Ts from targeting undesired cells, Shu and colleagues designed a CD47-specific CAR (with an anti-CD47 scFv as the targeting domain) that does not harbor any intracellular signaling domains (81).