IL1B and metabolic dysfunction-associated steatohepatitis: Subsequently case-control association study revealed rs361525 (G/A) at -238 of TNF-α and rs1143627(C/T) at -31 in IL1β were significantly associated with ALD as observed in discovery cohort of 322 patients, validation cohort of 100 patients and 50 patients in a non-linked NASH group.