Thus, we focused on upregulated immune genes only and genes were selected after validation in the liver tissue of ALD (n=4) and ALC (n=4) using customized qRT-PCR expression array which included immune genes associated to alcohol induced steatohepatitis and cirrhosis such as TLR4, IFN-α, CD14, MCP1, IL8, TGF-β, TNF-α, IL6, IL18, IFN-γ, IL22, IL17, IL10, CCR2 and complements C5 and C3 as found in the published literatures (19, 34, 35) and in the above two analyses. The gene discussed is IL22; the disease is Cirrhosis.