MICA and hepatocellular carcinoma: As an example of this possible outcome, our analysis showed that UTR4 have increased ΔG versus UTR1a/b/c for miR-20b-5p (Table 3), a miRNA that is upregulated in hepatocellular cancer (Zhang et al., 2014), suggesting that the presence of UTR4 could enhance down-expression of MICA by miR-20b-5p in this type of cancer; however, function assays are necessary to elucidate this MICA regulatory mechanism.