In the tumor environment, certain MICA variants that express methionine in the 129-amino acid (MICA-129 Met), such as the allelic variants *001, *002, *007, *011, *012, *015, *017, and *018 have been reported to exhibit a higher affinity for NKG2D receptor and potentially lead to a strong cytotoxic response (Isernhagen et al., 2016). The gene discussed is MICA; the disease is neoplasm.