Results from the multivariate logistic regression analysis revealed that IL‐4 (OR = 0.534, 95% CI: 0.385–0.741, p < .001), IL‐17 (OR = 0.914, 95% CI: 0.863–0.967, p = .002), and HDL‐C (OR = 0.148, 95% CI: 0.051–0.433, p < .001) were found to be independent predictors for CAD, in addition to gender (OR = 2.296, 95% CI: 1.281–4.115, p = .005), smoking (OR = 2.272, 95% CI: 1.151–4.485, p = .018), and diabetes (OR = 2.643, 95% CI: 1.313–5.321, p = .006) which were identified as classic independent risk factors for CAD. The gene discussed is IL4; the disease is coronary artery disorder.