Instead, AdAPT-001 is detargeted from non-tumor cells through the deletion of a small 50 base pair region located upstream of the E1A initiation site, which leads to abortive infection and no or restricted cytolytic activity in normal cells, but potent near wild type levels of replication, expression, and cytolytic activity in tumor cells [10–12]. This evidence concerns the gene DHTKD1 and neoplasm.