The mechanosensitive Piezo channels have been previously described in VSMCs and associated with structural remodeling of small arteries in hypertensive conditions, through regulating transglutaminase activity.[46] VSMC Piezo1 was further linked to  increased contraction and proliferation [17, 47] and apoptosis.[48] Additionally, Piezo1 was upregulated in abdominal aortic aneurysms downstream of netrin‐1.[49]. This evidence concerns the gene PIEZO1 and abdominal aortic aneurysm.