APP and liver dysplastic nodule: Many studies have reported that the expression of Nrf2 can be modulated by VDR,[22] and a recent study suggested that VDR activation could inhibit ferroptosis by mediating Nrf2 activation in APP/PS1 mice.[23] To further test the mechanism by which VDR activation regulates Nrf2 in the progression of ferroptosis in DN, we used the JASPAR database (http://jaspar.genereg.net) to predict the binding sites of VDR to NFE2L2 from both human and mouse homologous sequences (Figure5A).