VDR and acute kidney injury: A few studies have proposed that VDR activation exerts a nephroprotective effect in animal models of AKI by regulating the death mode of PTECs.[20] A growing body of evidence has confirmed VDR can mediate nongenomic pathways to respond to proximal tubulopathy, such as the AMP‐activated protein kinase (AMPK) and phosphoinositide 3‐kinase (PI3k) pathways.[30, 31] Our study focused on the early stage of DN, and we demonstrated that VDR activation could improve kidney function by inhibiting ferroptosis.