With the success in the use of SGLT2 inhibitors, the importance of tubular lesions in DN is getting more attention.[24] Recent studies have revealed that renal tubule ferroptosis plays an essential role in the development of DN.[25] The findings of this study revealed that PAR, an agonist of VDR, could protect against ferroptosis of PTECs and attenuate kidney injury in DN. The gene discussed is SLC5A2; the disease is liver dysplastic nodule.