Altered adipose tissue functions in most patients with obesity are associated with chronic inflammation‐induced immune cell infiltration and local microenvironmental remodeling.[56] A large amount of adipose tissue surrounds the mammary gland in mice.[57] Therefore, we hypothesized that impaired tissue thermogenesis in LINK‐A KI mice under HFD conditions was caused by the dysregulated inflammatory microenvironment. This evidence concerns the gene LINC01139 and Obesity.