We also used in vitro experiments to further reveal that under the regulation of the LINK‐A/HB‐EGF/HIF1α loop pathway, lncRNAs (such as LINK‐A) remodel the inflammatory microenvironment by inducing the expression of IL‐1β and CXCL16, thereby decreasing the surrounding adipocytes' thermogenic capacity, which seems to be crucial for promoting HFD‐induced obesity. The gene discussed is LINC01139; the disease is obesity due to melanocortin 4 receptor deficiency.