Here, by constructing an obesity‐associated human lncRNA LINK‐A knock‐in(KI) mouse model and an HFD‐induced obesity metabolic model, we found that LINK‐A plays a crucial role in the metabolic microenvironment and energy consumption cross‐talk in vivo by promoting obesity and metabolic disorders induced by the HFD. The gene discussed is LINC01139; the disease is Other metabolic disease.