Altered adipose tissue functions in most patients with obesity are associated with chronic inflammation‐induced immune cell infiltration and local microenvironmental remodeling.[56] A large amount of adipose tissue surrounds the mammary gland in mice.[57] Therefore, we hypothesized that impaired tissue thermogenesis in LINK‐A KI mice under HFD conditions was caused by the dysregulated inflammatory microenvironment. Here, LINC01139 is linked to obesity due to melanocortin 4 receptor deficiency.