AITL is a major PTCL subtype characterized by intense inflammation and immune reactions, and an elevated C‐reactive protein level is a poor independent prognostic factor for AITL.[16, 17] Single‐cell RNA sequencing (scRNA‐seq) is widely used to study hematological malignancies because of its extraordinary advantages in exploring cellular heterogeneity.[18, 19, 20, 21] We performed scRNA‐seq to examine the cellular identity and investigate the expression heterogeneity of the cGAS‐STING pathway, which is closely associated with inflammation and immunity in AITL. Here, STING1 is linked to angioimmunoblastic T-cell lymphoma.