In our study, RIP-qPCR, co-immunoprecipitation, RNA-pulldown, and costaining analysis validated the interaction of ALKBH5, lncRNA SNHG15, and SETD2, raising the possibility that they may constitute a triple complex and colocalize to specific chromatin regions, increasing chromatin accessibility and activating target gene transcription associated with MM tumorigenicity. This evidence concerns the gene SETD2 and Miyoshi myopathy.