After mapping the H3K36me3 peaks to normalizing input, we identified 42,634 H3K36me3 peaks from 8,422 genes in control MM cells, 37,219 H3K36me3 peaks from 8,073 genes in ALKBH5-depleted MM cells, and 43,045 H3K36me3 peaks from 8,653 genes in ALKBH5-depleted-SNHG15-overexpressed MM cells, confirming that ALKBH5-SNHG15 axis activated global transcription via H3K36me3 modifications. Here, SNHG15 is linked to Miyoshi myopathy.