The trimethylated histone H3 at lysine 36 (H3K36me3) methyltransferase SETD2 is prevalently mutated in many solid cancers and leukemia, and it is thought to modulate genomic instability and gene body-associated transcriptional elongation via catalyzing H3K36me3 (23–26). Here, SETD2 is linked to leukemia.