ALKBH5 and Miyoshi myopathy: We then performed DNase I-TUNEL assay and observed a notable decrease in chromatin accessibility after ALKBH5 depletion in RPMI8226 MM cells, which was remedied by lncRNA SNHG15 overexpression (Fig. 4D), and opposite tendencies were found in NCI-H929 cells cotransfected with LV-ALKBH5 and shSNHG15 as aforementioned (Supplemental Fig. S4A).