One of the genes, Ramp1, is associated with calcitonin-like ligand receptors, which is a highly potent vasoactive peptide that is protective against hypertension, and its early and sustained downregulation in the SHR corresponds to a loss of protection against autonomic dysfunction that primes the system for the subsequent development of hypertension (79). The gene discussed is RAMP1; the disease is hypertensive disorder.