With regard to genes encoding Na+ channels, Scn9a was persistently upregulated in the RVLM with the exception of 12 wk, whereas Scn8a and Scn1a appeared to show upregulation in the NTS around the onset of hypertension at 10 and 12 wk (Fig. 7B). The gene discussed is SCN8A; the disease is hypertensive disorder.