THBS1 and peripheral arterial disease: Increased expression of TSP-1 has been reported to be associated with thrombosis (Vallejo et al., 2000), which is significantly elevated in large vessels with atherosclerotic lesions (Smadja et al., 2011), peripheral arterial diseases (Huang et al., 2015), as well as AMI (Abdelmonem et al., 2017).