Treatments available for JIA include nonsteroidal anti-inflammatory agents, intra-articular corticosteroid injections, conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and biologic disease-modifying anti-rheumatic drugs (bDMARDs), including tumor necrosis factor inhibitors (anti-TNF), and other mechanisms of action (L-1 receptor antagonists, IL-6 receptor antagonists, anti–T cell–specific inhibitors). Here, TNF is linked to juvenile idiopathic arthritis.