The diagnosis of PSP is definitively determined through neuropathological examination, revealing the accumulation of intracerebral aggregates of the microtubule-associated protein tau (4R-tau) in neurofibrillary tangles, oligodendrocyte coils, and astrocytic tufts (Barsottini et al., 2010; Höglinger et al., 2017). Here, MAPT is linked to supranuclear palsy, progressive, 1.