The neuroprotective effects of sulfuretin in Alzheimer’s disease are thought to occur through activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent heme oxygenase-1 (Ho-1) expression via the PI3K/Akt signaling pathway (Kwon et al., 2015). This evidence concerns the gene AKT1 and early-onset autosomal dominant Alzheimer disease.