ACE2 and liver disorder: Studies have found that liver dysfunction caused by SARS-CoV-2 may be the result of multiple factors, including viral replication mediated by ACE-2 in the liver, direct viral-mediated damage, hypoxia or ischemic injury, immune-mediated inflammatory response, drug-induced liver injury, or exacerbation of pre-existing liver disease (Aleem and Shah, 2022; Antinori et al., 2011).