This study also found that hypocalcemia can serve as a predictive factor for disease progression to severe cases, which may be related to the impaired coagulation function, reduced myocardial contractility, and abnormal regulation of various enzymes such as protein kinase C, adenylate cyclase, and tyrosine hydroxylase in the presence of hypocalcemia. The gene discussed is ADCY1; the disease is Hypocalcemia.