After adjusting for body mass index (BMI), hemoglobin (Hb), N-terminal pro-B-type natriuretic peptide (NTproBNP), estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG), cardiac troponin-I (TnI), ejection fraction (EF), systolic blood pressure, diastolic blood pressure, heart rate, total cholesterol, calcium, history of smoking, diabetes mellitus, and hypertension, RCS was used to analyze the association between CACS and the risk probability of coronary stenosis ≥50% and 70%. The gene discussed is NPPB; the disease is Hypertension.