ACHE and Alzheimer disease: Therefore, as part of our ongoing research program toward exploiting novel anti-AD bioactive molecules (Wan et al., 2021a; Wan et al., 2021b; Wan et al., 2021c; Miao et al., 2021; Xu et al., 2023; Zhang et al., 2023), the present work pay attention to the AChE inhibitory activity affected by the benzyl moiety in donepezil, and proposed the structural modification of donepezil for efficiently introducing aromatic nitrogen heterocycles or aryl functional groups located at N position via Palladium-catalyzed Buchwald-Hartwig reaction, hoping to find the potential bioactive molecules.