In addition, several genes known to play a key role in progression of osteoarthritis (e.g., Fgf2, Ep300, Ngf, Adam9, Igfbp3, Sox9, Comp, Col6a1, Col6a2 and Col11a1) were modulated in our injurious hydrostatic pressure hip cap datasets, thereby validating this approach. The gene discussed is COMP; the disease is osteoarthritis.