In addition, several genes known to play a key role in progression of osteoarthritis (e.g., Fgf2, Ep300, Ngf, Adam9, Igfbp3, Sox9, Comp, Col6a1, Col6a2 and Col11a1) were modulated in our injurious hydrostatic pressure hip cap datasets, thereby validating this approach. This evidence concerns the gene COL6A1 and osteoarthritis.