Further analysis of these enriched pathways in injurious hydrostatic pressure highlighted differential expression of several genes known to be involved in osteoarthritis, such as Fgf2, Ep300, Ngf, Adam9, Igfbp3, Sox9, Comp, Col6a1, Col6a2 and Col11a1. The gene discussed is IGFBP3; the disease is osteoarthritis.