Moreover, the ROC analysis indicated that the AOD values of ERBB3 protein immunohistochemical positive staining could serve as a promising diagnostic biomarker for determining the occurrence of lymph node metastasis in THCA cases (AUC=0.89, 95%CI 0.73-1.00; Figure 11C). Here, ERBB3 is linked to metastatic malignant neoplasm in the lymph nodes.