The Wilcoxon rank sum test showed that several anti-tumor immune pathway activation was significantly higher in cholesterol-silence cluster than in metabolic-active cluster, including activated CD4 T cell, type17 T-helper cell, and several pro-tumor immune pathway activations were significantly higher in metabolic-active cluster than in cholesterol-silence cluster, including macrophage, MDSC, and plasmacytoid dendritic cell (Figure 2F). The gene discussed is CD4; the disease is neoplasm.