We corrected some confounding factors (DN, DR, DPN, DF, insulin use history, biguanide use history, thiazolidines use history, antihypertensive drug use history, hypertension history, A/G, ACR, TC, TG, HDL, LDL, eGFR, P, Ca, HbA1c, serum C-peptide). The gene discussed is INS; the disease is Hypertension.