The results showed that after adjusting for confounding factors (DN, DR, DPN, DF, history of insulin use, history of biguanides use, history of thiazolidines use, history of antihypertensive drugs use, history of hypertension use, ACR, TC, TG, HDL, LDL, eGFR, P, Ca, HbA1c, serum C peptide). Here, INS is linked to hypertensive disorder.