After adjusting for the confounding factors of diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, diabetic foot, history of use insulin, history of use biguanide drugs, history of use thiazolidines drugs, history of use antihypertensive drugs, A/G, ACR, TC, TG, HDL, LDL, eGFR, P, Ca, HBA1C and serum C-peptide, linear regression was used to analyze the relationship between onset age and ASMI, TFMI, A/T, A/G. This evidence concerns the gene INS and diabetic retinopathy.