SELE and cancer: These cytokines interact in an autocrine/paracrine manner with the vascular endothelium to increase the expressions of the endothelial cell surface adhesion molecules E-selectin, ICAM-1 and VCAM-1, resulting in increased endothelial adhesion of cancer cells and increased migration of endothelial cells, with formation of tubules and branch points (angiogenesis) (40).