NFKB1 and neoplasm: Interestingly, it is well established that inhibition of autophagy can suppress NF-κB-mediated inflammation (57), which further supports a non-canonical pathway adopted by ART through which it downregulates CLEC12A, inhibits autophagy, decreases expressions of NF-κB (RelA) and JNK/pJNK, and reduces inflammation in the tumor cells, eventually culminating in cell death.