CASP3 and neoplasm: To further validate this data, western blot analysis was performed, and a decrease in expression of anti-apoptotic protein (Bcl-2) and an increase in expression of pro-apoptotic proteins (Bax, cleaved caspase 3 and cleaved PARP) was evident in tumor tissues of ART-treated tumor-bearing mice compared to the untreated tumor-bearing mice (Figure 2G).