AQP4 and Seizure: Many reports have focused on this topic and several factors have been explored such as inflammation (Gorter et al., 2015), poor sleep quality (Reddy and van der Werf, 2020), impaired aquaporin 4 water channel (Lohela et al., 2022), glutamate overproduction and glutamate receptor overactivation after epileptic seizures (Gorter et al., 2015; Dadas et al., 2016).