The results of the univariate analysis showed that tumor marker CA199, tumor size, TNM stage, distant metastasis, lymph node metastasis, mGPS score, Ki-67 positive expression rate, anemia type, and other aspects were related factors affecting the prognosis of colorectal cancer patients undergoing radical surgery (P < 0.05, Table 4). The gene discussed is MKI67; the disease is anemia.