IL4 and allergic asthma: Signaling cascades dependenton JAK1 play a pivotal role in the pathophysiology of allergic asthma,rendering them attractive targets for therapeutic intervention.16 JAK1 phosphorylates and activates the intracellularsignal transducer and activator of transcription 6 (STAT6), therebyorchestrating the transcription of downstream target genes.17 Several cytokines connected with type 2 inflammation,including IL-4 and IL-13, communicate signals through the JAK-STATpathway.18 In this study, the activationof JAK1 and the subsequent activation of STAT6 were induced by IL-4and IL-13.