SERPINE1 and cancer: It has been observed that PAI-1 directly inhibits mitochondrial function, facilitating the switch from oxidative phosphorylation to glycolytic metabolism in TNBC (Humphries et al., 2020), and therefore continued investigation into PAI-1, its potential position in excision repair pathways, including NER and BER, along with its involvement in Acetyl-CoA production, is integral to understanding cancer metabolism and chemoresistance.