SERPINE1 and cancer: PAI-1 expression is induced during EMT, tissue repair, and cancer cell dissemination (Kalluri and Weinberg, 2009), and it is not out of the question to suggest that PAI-1 functions as a morphogen within the scope of cancer genesis, progression, and metastasis, including in HGSOC, and that platelets contribute to the gradient on which PAI-1 operates, tempered by neutrophil recruitment within the inflammasome.