A list of genes associated with cell migration was used to create a gene map (Figure 2D), which contained both known and predicted protein-protein interactions demonstrating that SERPIN E1 is central to many of the biological processes involved in ovarian cancer metastasis, including negative regulation of cell adhesion mediated by integrin, regulation of wound healing, positive regulation of interleukin-8 (IL-8) production, regulation of cell-matrix adhesion, regulation of cell migration, and positive regulation of angiogenesis. This evidence concerns the gene CXCL8 and ovarian carcinoma.