SERPINE1 and cancer: Significant downregulation of mechanisms associated with phosphorylation was observed when PAI-1 was silenced, and has potential implications for protein function and signal transduction, inflammation, apoptosis, molecule transport across cell membranes, and - crucially - oxidative phosphorylation, which when coupled with the dysregulation of Acetyl-CoA production further implicates PAI-1 in cancer cell metabolism.