SERPINE1 and ovarian cancer: PAI-1 and Platelets augment Gene Expression in Metastatic Pathways in Ovarian Cancer Cells A cluster analysis (Figure 2A) demonstrated differentially-expressed genes (DEGs), with downregulation (blue) and upregulation (red) of genes corresponding to treatment types: untreated cells (UNT), cells treated with a negative control (siNEG), cells where PAI-1 had been silenced (siRNA), platelets added to untreated cells (UNT + P), platelets added to cells treated with a negative control (siNEG + P), or platelets added to cells where PAI-1 had been silenced (siRNA + P).