Although API5 and Hsp20 showed the same variation trend after virus infection, the up-regulation amplitude of API5 was much larger than that of Hsp20 from both mRNA and protein levels, indicating that API5 and Hsp20 were mutually antagonistic, at the same time, 24 h after virus infection, the virus could inhibit apoptosis through the high expression of API5, thus exercising its immune escape function. The gene discussed is API5; the disease is viral infectious disease.