He was admitted to the intensive care unit, and a broad infectious workup revealed a new diagnosis of advanced HIV (HIV RNA = 470 000 copies/mL; CD4 = 13 cells/mm3; CD4% = 15.1%), miliary TB without evidence of TB meningitis, disseminated histoplasmosis, and fungal endophthalmitis. The gene discussed is CD4; the disease is meningitis.