Notably, the EGFR decrease in HF-fed Maf1hep−/− mice (Figure 4A; Figure 5) mentioned above may be linked to the Angiogenin decrease, since Angiogenin was recently identified as a potent EGFR ligand in humans (Wang et al., 2018; Wang et al., 2019). This evidence concerns the gene EGFR and hydrops fetalis.