Several signaling pathways, including Transforming Growth Factor-β1 (TGF-β1) (55), both canonical and noncanonical Wnt (56, 57), Notch (58), and the Nuclear Factor Erythroid-2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 (Nrf2-Keap1) pathways (59), have been implicated in the fibrosis triggered by inflammatory responses in DKD (60). This evidence concerns the gene KEAP1 and diabetic kidney disease.