S-III was enriched with pathways involved in cancer progression such as pathways in cancer (hsa04330), Notch signaling pathway (hsa04330), osteoclast differentiation (hsa04380), insulin signaling pathway (hsa04910), regulation of actin cytoskeleton (hsa04810), and endocrine and other factor-regulated calcium reabsorption (hsa04961). The gene discussed is INS; the disease is cancer.