In addition, a recent study showed that miR-548d-3p has an important role in CL caused by L. braziliensis since inhibition of this miR in infected THP-1 cells was associated with reduced parasite growth early after infection and increased the production of molecules such as MCP1/CCL2, RANTES/CCL5, and IP10/CXCL10, data corroborated in the plasma of individuals with active or cured disease compared to controls (28). The gene discussed is CXCL10; the disease is infection.