The third pathological investigation of the right paravascular iliac lesion indicated that the lymphoma had transformed into DLBCL (GCB subtype) that was negative for CD20 and positive for Bcl-6 (90%+), MUM1 (90%+), Ki-67 (80%+), Bcl-2 (90%+), c-myc (60%+), CD10 (+), and CD19(+) (Figure 1B). This evidence concerns the gene MS4A1 and diffuse large B-cell lymphoma.