Recombinant antigen vaccine made up of Ag2/PRA (antigen 2/PRA) and CSA (Coccidioides-specific antigen) has shown favorable survival in mice suffering from coccidioidomycosis (313), caused by the endemic fungi Coccidioides immitis in immune-competent individuals in the southwestern United States and northwestern Mexico. This evidence concerns the gene S100A6 and coccidioidomycosis.